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|EINECS No:||262-640-9||Type:||Antibiotic And Antimicrobial Agents|
|Grade Standard:||Medicine Grade||Usage:||Animal Pharmaceuticals|
|Purity:||99%min||Product Name:||AMoxicillin And Clavulanate Potassium|
|Appearance:||White Powder||Grade:||Pharmaceutcial Grade|
|Assay:||HPLC 99%||Shelf Life:||2 Years|
|Application:||Pharmaceutical Raw Intermediates|
medicine raw material,
tiamulin hydrogen fumarate
High Purity Pharmaceutical Raw Materials AMoxicillin And Clavulanate Potassium CAS: 61177-45-5
Chinese name: Amoxicillin And Clavulanate Potassium Powder
CAS No.: 61177-45-5
Molecular Formula: C8H8KNO5
Molecular Weight: 237.2511
Grade Standard: Medicine Grade
Quality Standard: BP/EP/USP
Appearance: White or yellowish crystalline powder
Usage: Animal Pharmaceuticals.
Application: Pharmaceutical Raw Intermediates
It is white or yellowish crystalline powder; Slight odor. Very easy to get wet. It is easily soluble in water, soluble in methanol, slightly soluble in ethanol, insoluble in ether. Boiling point 545.8°C at 760 mmHg, Flash point 283.9°C, Vapour Pressur 3.45E-14mmHg at 25°C.
|Appearance||White or almost white crystalline powder hygroscopic||White powder, hygroscopic|
|Identification Tests||HPLC: The principal peaks in the chromatogram obtained with the test solution is similar in retention time to that obtained with reference solution||Conform|
|Ratio of compound||Amoxicillin:clavulanic acid(1.9~2.1):1||2.0:1|
|Related substances||Any individual impurity(largest), NMT 2.0%||0.12%|
|Total impurities, NMT 5.0%||0.52%|
|Assay on the anhydrous basis||Clavulanic acid, NMT25.8%||30.9%|
|Conclusion||The results conforms with enterprise standards|
1. Clavulanic Acid is a β-lactamase inhibitor, typically added to amoxicillin to increase its effectiveness.
2. Clavulanic acid is a β-lactam antibiotic produced by several species of Streptomyces. The free acid degrades and is isolated and maintained as either the sodium or potassium salt. Clavulanate is a weak antibiotic, but is a potent inhibitor of β-lactamases. In combination with penicillin and cephalosporins, it shows potent synergistic activity. Clavulanic acid is a suicide inhibitor, covalently binding to a serine residue in the active site of the β-lactamase.
3. A -Lactamase inhibitor, typically added to amoxicillin to increase its effectiveness.
25kg/drum, 1kg/ aluminium foil bag, Or according to your requirement.
Store in a shady place, keep sealed. Storage Condition 2-8ºC.
AMoxicillin and Clavulanate Potassium is not reversible competitive inhibitors of beta-lactamase, firmly binding enzyme inactivation of the enzyme, so powerful, not only gold aureus of beta-lactamase, and Gram-negative bacilli of beta-lactamase. Penicillins, cephalosporin class combined with greatly increased antimicrobial activity, can make the minimum inhibitory concentration (MIC) decreased drug effect several times to more than 10 times, drug-resistant strains to recover its sensitivity. This product is also known as clavulanic acid, new oxygen nucleus produced by Streptomyces β-lactam antibiotics. Potassium clavulanate for the needle-like crystals, soluble in water.
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